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Metrics details. Congenital myopathy CM is a group of clinically and genetically heterogeneous muscle disorders, characterized by muscle weakness and hypotonia from birth. Currently, no definite treatment exists for CM. Histopathological, swimming behavior, and muscle endurance were monitored in TPM3 wild-type and mutant transgenic fish, modelling CM. Gene expression profiling of muscle of the transgenic fish were studied through RNAseq, and mitochondria respiration was investigated. Interestingly, l -carnitine treatment on TPM3 EG transgenic larvae significantly improves the muscle endurance by restoring the basal respiration and ATP levels in mitochondria.
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A civil union also known as a civil partnership is a legally recognized arrangement similar to marriage , created primarily as a means to provide recognition in law for same-sex couples. Civil unions grant most or all of the rights of marriage except the title itself. Around the world, developed democracies began establishing civil unions in the late s, often developing them from less formal domestic partnerships , which grant only some of the rights of marriage. In the majority of countries that established these unions in laws, they have since been either supplemented or replaced by same-sex marriage.
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