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Granular cell tumor of the breast: a case report
Granular cell tumor of the breast: a multidisciplinary challenge
Many conditions affect the human integumentary system —the organ system covering the entire surface of the body and composed of skin , hair , nails , and related muscle and glands. The epidermis is the most superficial layer of skin, a squamous epithelium with several strata : the stratum corneum , stratum lucidum , stratum granulosum , stratum spinosum , and stratum basale. The epidermis contains four cell types: keratinocytes , melanocytes , Langerhans cells , and Merkel cells. Of these, keratinocytes are the major component, constituting roughly 95 percent of the epidermis. The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary dermis and the reticular dermis. The subcutaneous tissue is a layer of fat between the dermis and underlying fascia.
Benign granular-cell tumour of the breast
An oncocytoma is a tumor made up of oncocytes , epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli. Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma.
These changes are sometimes called fibrocystic changes , and used to be called fibrocystic disease. Areas of fibrosis feel rubbery, firm, or hard to the touch. They are often felt as a round, movable lump, which might also be tender to the touch. Cysts begin when fluid starts to build up inside the breast glands. These can be felt easily and can be as large as 1 or 2 inches across.